Research

RESEARCH FOCUS

Somatic cell reprogramming is the process by which enforced expression of defined embryonic transcription factors (TF) in somatic cells changes their fate to induced pluripotent stem cells (iPSC).

APPROACH

We use high-throughput sequencing techniques such as 4C-Seq, HiC, ChIP-seq and RNA-seq. We also employ biochemical, molecular, and cell biology assays, as well as novel mouse genetics tools.

PROJECTS

• Regulation of imprinted gene expression.

• Coregulation of linage-related genes during differentiation.

• Role of pluripotency factors and cofactors in establishment and maintenance of interactions