Effie Apostolou, PhD

Assistant Professor of Molecular Biology in Medicine

Department of Medicine

Division of Hematology/Oncology

Cancer Center

Weill Cornell Medical College

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Research

RESEARCH FOCUS

Somatic cell reprogramming is the process by which enforced expression of defined embryonic transcription factors (TF) in somatic cells changes their fate to induced pluripotent stem cells (iPSC).

APPROACH

We use high-throughput sequencing techniques such as 4C-Seq, HiC, ChIP-seq and RNA-seq. We also employ biochemical, molecular, and cell biology assays, as well as novel mouse genetics tools.

PROJECTS

  • Regulation of imprinted gene expression.

  • Coregulation of linage-related genes during differentiation.

  • Role of pluripotency factors and cofactors in establishment and maintenance of interactions

People

Effie Apostolou, PhD

Principal Investigator

Dafne Campigli di

 

Giammartino, PhD

 

NYSCF Postdoctoral Fellow

Boaz Aronson, MD/PhD

Postdoctoral Researcher

Alex Polyzos, PhD

Computational Postdoctoral Researcher

Laurianne Scourzic, PhD

Postdoctoral Researcher

Dylan Murphy

PhD Student

Veevek Shah

Lab Manager

 

Bobbie Pelham-Webb

MD/PhD Student

 

News

09/23/2019
Our paper on 3D-enhancer rewiring during reprogramming is out in Nature Cell Biology. Great work everyone! 
Link for the article: here 
Link for commentary: here 

03/05/19
Bobbie is awarded an NIH F30 Fellowship from the National Institute for Child Health & Human Development (NICHD) for her work on Mitotic Bookmarking. Congrats Bobbie!
03/01/18
Our paper on Mitotic Bookmarking is among the 10 Best of Cell Reports in 2017! 
Download the PDF to see all 10 articles: here 
06/22/17
Laurianne is awarded the Lady Tata Memorial Trust Fellowship. Congratulations Laurianne!
10/04/16
Effie gets the NIH Director's New Innovator award!!! Big news for the lab & big celebrations :)
See the full list of Awardees: here 
See featuring article: here 

Contact

Effie Apostolou

 

Weill Cornell Medical College

Belfer Research Building, Room 1418

413 East 69th Street,New York, NY 10021

 

efa2001@med.cornell.edu  |  Tel: 646-962-6235