Effie Apostolou, PhD
Assistant Professor of Molecular Biology in Medicine
Department of Medicine
Division of Hematology/Oncology
Weill Cornell Medical College
Somatic cell reprogramming is the process by which enforced expression of defined embryonic transcription factors (TF) in somatic cells changes their fate to induced pluripotent stem cells (iPSC).
We use high-throughput sequencing techniques such as 4C-Seq, HiC, ChIP-seq and RNA-seq. We also employ biochemical, molecular, and cell biology assays, as well as novel mouse genetics tools.
Regulation of imprinted gene expression.
Coregulation of linage-related genes during differentiation.
Role of pluripotency factors and cofactors in establishment and maintenance of interactions