Effie Apostolou, PhD
Assistant Professor of Molecular Biology in Medicine
Department of Medicine
Division of Hematology/Oncology
Cancer Center
Weill Cornell Medical College
Research
RESEARCH FOCUS
To understand the complex functional interplay between transcription factors and 3D chromatin architecture and the impact on cell fate decisions, such as reprogramming, differentiation or tumorigenesis.
APPROACH
We use high-throughput sequencing techniques such as 4C-Seq, HiC, HiChIP, ChIP-seq and RNA-seq and integrative computational analysis to dissect regulatory mechanisms of cell type-specific gene expression programs. We also employ advanced CRISPR/(d)Cas9-based genetic and epigenetic approaches for functional validation.
PROJECTS
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Delineating the mechanisms of cell fate inheritance after cell division.
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Dissecting the nature, role and major driving forces of 3D chromatin reorganization during cell fate transitions.
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Defining critical proteins and regulatory elements that control epigenetic stability of genomic imprinting.
People
Effie Apostolou, PhD
Principal Investigator
Dafne Campigli di
Giammartino, PhD
NYSCF Postdoctoral Fellow
Boaz Aronson, MD/PhD
Postdoctoral Researcher
Alex Polyzos, PhD
Computational Postdoctoral Researcher
Laurianne Scourzic, PhD
Postdoctoral Researcher
Dylan Murphy
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PhD Student
Veevek Shah​
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Lab Manager
Bobbie Pelham-Webb
MD/PhD Student
News
July 2020: Our research on 3D regulatory hubs in early developmental decisions is funded by an R01 from NIGMS. So excited to dive into the organizational principles and the functional impact of these hubs!!! So many reasons to celebrate finally in person! Let's sail!
May 2020: Dylan is selected for the T32 Training Grant in Developmental & Stem Cell Biology. So many reasons to celebrate!
March 2020: Laurianne is awarded a fellowship from the Lymphoma Research Foundation for her efforts to dissect the stem-like properties of Germinal Center B cells and their implications in lymphoma. In addition, she obtained a Core Facility seed grant from the Cornell Center for Immunology! We are so proud of you!!!
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September 2019: Effie presents at the CSHL Stem Cell Biology meeting
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September 2019: Our paper on 3D-enhancer rewiring during reprogramming is out in Nature Cell Biology. Great work everyone!
Link for commentary: here
July 2019: Boaz is awarded an MTOR T32 training grant for his project on mechanisms of imprinting maintenance. Congratulations!!!
June 2019: Farewell lunch and rowing at Central Park for Dafne! We miss you already!
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May 2019: Effie presents at the EMBO 3D genome workshop at Kyllini. Magical place and incredible audience!
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March 2019: Bobbie is awarded an NIH F30 Fellowship from the National Institute for Child Health & Human Development (NICHD) for her work on Mitotic Bookmarking. Congrats Bobbie!
Contact
Effie Apostolou
Weill Cornell Medical College
Belfer Research Building, Room 1418
413 East 69th Street,New York, NY 10021
| Tel: 646-962-6235